Life possesses "resilience" (しなやかさ)—the ability to adapt to various stresses such as mechanical forces, pH fluctuations, and temperature changes. This "resilience" is fundamental to sustaining life, yet its underlying mechanisms remain unclear. We believe that the dynamics of critical regions within the plasma membrane microenvironment ("critical membrane sites") hold the key to understanding "resilience". By elucidating the properties and roles of these "critical membrane sites", we aim to bridge the microscopic "critical membrane sites" with the macroscopic "resilience" observed at the cellular, organ, and organismal levels. Through this approach, we seek to establish a new research perspective—"Resilience Biology" (しなやかさ生物学)—to uncover the fundamental principles that govern cellular and biological functions.